Dexamethasone suppression test status and severity of depression
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چکیده
منابع مشابه
Dexamethasone suppression test status and severity of depression.
Many patients with major depressive disorder (MDD) develop state-dependent hypotbalamicpituitary-adrenal (HPA) axis dysregulation (Carroll et al. 1981). A complex interaction of factors contributes to this abnormality. Severity of illness (Kumar et al. 1986; Meador-Woodruff et al. 1987; Miller and Nelson 1987), age (Oxenkrug et al. 1983; Davis et al. 1984; Lewis et al. 1984), and degree of rece...
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Baseline plasma Cortisol levels and response to dexamethasone in a group of twenty five patients with ma) or depressive disorder (MDD) and a control group of twenty five patients with psychiatric diagnoses other than MDD were estimated. The results of our study show that dexamethasone suppression test (DST) is a useful diagnostic aid in MDD with melancholia with a sensitivity of 46% and specifi...
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Overnight post dexamethasone plasma Cortisol levels were estimated in thirty patients of major depression and 30 controls. The cut-off point after which post dexamethasone plasma Cortisol level could be considered abnormal, in patients of major depression, has been worked out at 15 μg/dl in the present study. The results are discussed.
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Acute caffeine administration increases cortisol and converts the dexamethasone suppression test (DST) to nonsuppression in normal humans; data concerning chronic administration as well as effects in depressed patients are minimal. To determine whether caffeine intake influenced DST results in depression, we retrospectively studied the relationship between regular daily caffeine consumption and...
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Hypercortisolemia, as measured by baseline serum Cortisol levels (Carroll and Mendels, 1976) and abnormal response to dexamethasone suppression test (DST) (Carroll et at., 1981) is thought to characterize abnormal hypothalamic-pituitory- adrenal (HPA) axis functions in patients of depression. Whether adrenocorticotrophic hormone (ACTH) shows similar abnormalities is a matter of controversy. Whe...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 1988
ISSN: 0006-3223
DOI: 10.1016/0006-3223(88)90143-6